The top half of the men’s quarter-final draw was completed on Thursday with Milos Raonic and Dominic Thiem now set to meet in the semi-finals on Saturday.
Friday sees the bottom half of the draw play and in the second match of the day, Nadal faces Russian Karen Khachanov.
Their last meeting was an enthralling battle at the US Open with Nadal fighting back from a set down.
Khachanov is yet to beat Nadal in their five previous matches but feels confident he can cause an upset.
“He’s one of the best tennis players, great champion,” said Khachanov.
“I’m playing better, feeling more confident.
“It will be a good challenge, good match for me.
“I’m really looking forward to have a good match against him.”
Rafael Nadal vs Karen Khachanov live stream – how to watch
Coverage of Rafael Nadal’s match against Karen Khachanov is being broadcast on Amazon Prime Video.
This year, Prime Video will broadcast on-site, live studio coverage across tournaments, including at the BNP Paribas Open from Indian Wells, the Fever Tree Championships from The Queens Club, the US Open, and the Nitto ATP Finals from The O2.
On-site field reporters will bring customers the latest action, analysis and commentary right from the court side at many tournaments.
In addition to 37 ATP Tour events and the US Open available exclusively on Prime Video with a Prime membership, Prime members in the UK who subscribe to Eurosport Player through Prime Video Channels for an additional £6.99 per month (following a 7-day free trial) will also benefit from full coverage of the French Open, and daily highlights and live coverage from the men’s and women’s finals of Wimbledon in 2019.