Barcelona could move 12 points clear of Real Madrid with a win at the Bernabeu.
Tonight’s El Clasico takes place just days after Barcelona ran out 3-0 winners in the Copa Del Ray.
And the Catalan club could inflict further misery on their La Liga rivals, who have endured a rough season after losing Cristiano Ronaldo to Juventus.
Real Madrid are currently nine points behind Barcelona in La Liga, and two points behind local rivals Atletico.
Real will also have one eye on Tuesday’s Champions League game with Ajax, which they lead 2-1.
Barcelona have no such concerns, as they don’t play Lyon in the Champions League until March 13.
If you don’t want to miss a second of the action, check out Express Online’s guide to live streaming below…
How to watch Real Madrid vs Barcelona online…
You can watch all of today’s action live and on demand via Eleven Sports 1 with the match kicking off at 7.45pm UK time.
This new service is available online at elevensports.uk and via the Eleven Sports iOS and Android apps.
A monthly content subscription costs just £5.99.
Eleven Sports says it will be showing five top-flight domestic leagues live and exclusive in the UK and Ireland.
These include La Liga, Serie A, Eredivisie, Chinese Super League (from 2019), Allsvenskan.
At least one match per week from both La Liga and Serie A will be shown live and free of charge on Eleven Sports’ UK Facebook Page.
A selection of games from the other top-flight football leagues available on Eleven Sports will also be shown on Facebook across the season.