Chelsea sit fourth in the Premier League going into the trip to face their cross-city rivals at Selhurst Park.
And they return to action off the back of a crucial win over Watford which has kept them above fifth-place Arsenal.
The victory at Vicarage Road came at a cost for Chelsea though, with Pedro and youngster Callum Hudson-Odoi both suffering injuries.
Pedro limped off and was replaced by Hudson-Odoi just before the break, only for the 18-year-old to be withdrawn himself five minutes from time.
Maurizio Sarri has now confirmed both players injured their hamstrings against Watford, with Pedro set to miss the visit to Palace.
“We have two problems, the first is more serious with Pedro,” Sarri said.
“He has an injury in his hamstring and I think that he will have to rest for about 10 days.
“The second problem is Odoi, it’s not very serious but I don’t know if he will be able to play in the next match.”
Sarri had a more promising prognosis on Alvaro Morata, who was left out against Watford.
“Morata now is going very well, he is fit to play,” Sarri added.
“It was only a tactical choice [to not play him against Watford].”
Chelsea are 11 points adrift of Premier League leaders Liverpool with half of the season played.
And Sarri says only Manchester City can prevent Jurgen Klopp’s side from winning the title.
“You know very well my opinion,” Sarri said, when asked if Chelsea could challenge for glory.
“As I said from the beginning, there are two teams a step ahead of the others, Liverpool and Man City.
“Now there is a little gap but I think City will be able to cover the gap, I think the title will be fought for between City and Liverpool.”