Jose Mourinho’s side have struggled this season and already sit seventh in the table, 14 points adrift of Manchester City.
But the shock prediction made by the table generated by Football Web Pages suggests United will end up an enormous 51 points behind Pep Guardiola’s side.
And Arsenal are the other team to miss out on Champions League qualification with Tottenham finishing five points aead of them.
At the other end of the table Crystal Palace, Southampton and Huddersfield are the three teams said to be on their way to the Championship.
Things are so bad at United that the Super Computer suggests Bournemouth will finish sixth ahead of them on goal difference.
Liverpool are set to chase City hard and finish on 105 points – a total which would usually win you the Premier League title.
But such is the form of Guardiola’s side they are set to record a massive 110 points and be crowned champions again.
Chelsea will finish on 92 points with Spurs on 85 as the duo both make it into next season’s Champions League.
This weekend will see Arsenal take on rivals Tottenham with Liverpool also facing a derby against Everton.
The Super Computer reckons the Gunners will draw 1-1 with Spurs.
But Liverpool are set to record a 2-0 victory against their rivals.
It us also suggested Manchester United, City and Chelsea are all set to win as well this weekend.
Premier League fixtures
All kick-off 3pm unless stated
Cardiff v Wolves (8pm)
Crystal Palace v Burnley
Huddersfield v Brighton
Leicester v Watford
Man City v Bournemouth
Newcastle v West Ham
Southampton v Man Utd (5.30pm)
Chelsea v Fulham (12pm)
Arsenal v Tottenham (2.05pm)
Liverpool v Everton (4.15pm)