At the rally, Trump was joined by his daughter Ivanka Trump, his Press Secretary Sarah Huckabee Sanders and counsel to the president Kellyanne Conway.
The trio looked to get the crowd motivated to go vote in the elections the following day as both democrat and Republicans make a final push to try and gain or maintain a majority in Congress.
Ms Trump told the Indiana crowd to “get out and vote tomorrow”.
She had also made an appearance at another rally in Cleveland earlier that day.
She later added: “A lot of people know me in my official capacity, and it’s one of the greatest honours of my life, to serve in your administration, and one of the most important jobs I’ll ever have.
“But the greatest job I’ll ever have, and the greatest title I’ll ever have, is that of a mum.
“And that’s why I work for this President, because I care about my kids’ future, and I care about the future of this country.”
Speaking about the incumbent Democrat Indiana Senator, Joe Donnelly, Mrs Conway said: “Let me just say in my personal capacity, because this election is very personal to me, Joe must go!
“Get him out!”
This is the second of three rallies that Trump is holding before election day.
Before this rally, Trump was in Ohio with his daughter.
His final rally will be in Missouri where he will be joined by FOX News anchor Sean Hannity, although he has recently clarified that he will not be appearing on stage with the President.
Mr Hannity said: “In spite of reports, I will be doing a live show from Cape Girardeau and interviewing President Trump before the rally.
“To be clear, I will not be on stage campaigning with the President.
“I am covering the final rally for my show. Something I have done in every election in the past.”