Week 9 of the NFL season gets underway with both teams searching for their second win of the year.
The Niners have suffered plenty of injuries with quarterback Jimmy Garoppolo out for the season with running back Jerick McKinnon suffering the same fate.
Antone Exum Jr , Jaquiski Tartt and Reuben Foster will also miss the clash while Matt Breida and Richard Sherman are among the questionable players.
For the Raiders, a lot rests on Derek Carr. The QB has thrown for 901 yards in his last three road games and will prove vital again.
Marshawn Lynch is out though with his return date still unknown.
Indeed, Raiders coach Jon Gruden has admitted even he is unsure when Lynch will take to the field again.
“I don’t know. I would say it would be very difficult [to return this season], but I’m never going to shut the door with a guy like that,” he said.
“We’ve got a number of players, we already talked about (defensive tackle Justin Ellis) and Donald Penn, where we will see what happens with how fast they heal.”
But who will get their second win of the season? Here’s how to watch.
How to watch Raiders vs 49ers LIVE on TV
The opening game of NFL Week 9 is live on Sky Sports with the match scheduled to begin at 12.20am.
Sky Sports Action will show the match with coverage getting underway at 11.30pm.
American viewers can watch the match on FOX.
How to stream Raiders vs 49ers LIVE online
Sky subscribers can live stream Oakland Raiders vs San Francisco 49ers online via SkyGo and the SkyGo app.
The match can be followed live on your desktop or laptop via the Sky Go app, which if you’re an existing customer, is also available on iOS and Android smartphone and tablet devices.
Sky Go is also available on a number of platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The Sky Sports app, available to download on iOS and Android devices, will also be providing live text coverage and updates.
If you’re not currently a Sky Sports customer but can’t stand to miss out on the action, you can add the channels to your box via a NOW TV subscription.
Day passes, which let you add Sky Sports channels for 24 hours, start at £7.99 a day, with a weekly pass starting from £12.99, and no locking in to a contract.
NOW TV doesn’t even require a typical television to use, as it is also available on a NOW TV Box, Chromecast, PS4, PS3, Xbox One, Xbox 360, Roku, LG Smart TV, PC or Mac, and selected mobile and tablet devices.