Mr Macron made the provocative comments during an interview with French newspaper Quest France.
He claimed: “Europe is facing a risk; that of dismemberment through nationalist leprosy and being pushed over by external powers.
“In a Europe that is divided by fears, nationalist assertion and the consequences of the economic crisis, we see almost methodically the re-articulation of everything that dominated the life of Europe from post-World War One to the 1929 crisis.”
In 1929 a run on the New York stock market pushed the world into economic and political turmoil, laying the ground for the rise of fascism in parts of Europe.
Controversially Mr Macron argued European sovereignty is being damaged by a reliance on Donald Trump’s America for its security.
He listed “having its security dependent on American choices and changes” as one of the main threats to European sovereignty along with Russian interference and growing Chinese influence within its energy markets.
Mr Macron noted his concern over the announcement by German Chancellor Angela Merkel that she won’t seek re-election when her premiership ends in 2021.
Mrs Merkel has also stepped down as leader of the governing centre-right Christian Democratic Union, amidst the ongoing rise of the hard-right Alternative for Germany (AfD) party.
Mr Macron claimed there is “nothing reassuring” about these announcements.
He added: “The far-right, I’ll remind you, is doing best of all in France.”
During the 2017 French presidential election Mr Macron defeated Marine Le Pen, leader of the far-right Front National, by 66 to 34 percent in the second round.
However, Mr Macron’s popularity has plummeted following his election.
An opinion poll published on Wednesday found his approval rating had slumped by another four points to just 26 percent.
A total of 71 percent of those asked said they had “no confidence” in his ability to govern the country.
Right-wing populists movement have been gaining ground across much of Europe in recent years.
In both Italy and Austria a party of the radical right is a minority partner in the governing coalition.
The AfD now has a presence in all 16 German state parliaments as well as the national Bundestag.
Recent polling suggests the party has the support of 17 percent of the German electorate.