At least 75 percent of the famous Italian lagoon city is under water following the record-breaking floods.
Venice often flood when high winds push water from the lagoon in.
When the tide reaches 43 inches (109cm), barriers are raised by the Prime Minister Giuseppe Conte.
This usually happens around four times a year and residents and businesses tend to barricade their doors with metal or wooden panel to stop water from getting in.
However, Monday saw water levels peaking at the highest seen since December 2008.
Tourists and residents have been forced to wear high boots to walk across the street, due to water levels reaching more than five feet.
People were also left stranded when transport officials closed the water-bus system, except to outlying islands.
Shops owners were pictured on social media using water pumps to protect their livelihoods.
A series of underwater barriers built in the lagoon could have prevented water levels reaching that high, the Mayor of Venice Luigi Brugnaro said.
A project for this, nicknamed Moses, is said to be in the pipeline.
But it is being severely delayed by cost overruns and corruption scandals.
But it is not just Venice suffering from rising water levels.
Vast swathes of Italy is currently under alert for flooding from heavy rains.
Major tourist attractions in Rome have been closed due to the rains, including the Colosseum and the Forum.
At least four people have been killed in Naples, Lazio and Liguria as recent flooding and heavy winds have resulted in trees toppling over.
The floods are being blamed on a lack of maintenance of the country’s river beds.
Veneto regional governor Luca Zaia warned the flooding could reach the levels of the 1966 flood that devastated Venice and Florence.
Around 101 people were killed by the 1966 flood of the Arno and millions of masterpieces of art and rare books were also destroyed.
The Interior Ministry is urging officials to keep school and offices closed today, in order to keep those who are trapped in storm-struck regions safe.