The dramatic rescue took place in North Carolina, USA, after the powerful storm wreaked havoc.
The dogs were set free just in time to escape the fast rising floodwaters.
Dramatic video footage showed the canines looking terrified, with their paws desperately pressed against the door, after it is understood their owners were forced to evacuate the danger zone.
Ryan Nichols, from Longview in Texas, was thought to have been the first to the rescue.
He waded through knee-high water to reach the cage following a rope that could be seen floating on the water surface.
Mr Nichols and other volunteers freed the dogs and all six had to swim to dry land.
Rescuer Marcus DiPaola, said on Twitter: “Rescued six dogs in Leland, NC, after the owner LEFT THEM locked in an outdoor cage that filled with flood water that was rapidly rising.
He added: ”We got them out, but by the time we left, the water was so high that they would have drowned. BRING YOUR PETS WITH YOU! #HurricaneFlorence.”
A video filmed by one of the rescuers has been viewed more than 1.39million times.
The death toll from Hurricane Florence had risen to 18 overnight, according to the Weather Channel – with 12 deaths recorded in North Carolina and six in South Carolina.
Among those killed was a three-month-old child, who suffered fatal injuries after a tree fell onto the family home, according to North Carolina Gaston County commissioner Tracy Philbeck.
North Carolina Governor Roy Cooper said: “Our hearts go out to the families of those who died in this storm. Hurricane Florence is going to continue its violent grind across our state for days. Be extremely careful and stay alert.”
A married couple also died in a house fire connected with the hurricane in Fayetteville, North Carolina.
Two further deaths were recorded in Duplin County, North Carolina on Saturday.
North Carolina’s energy company, Duke Energy, estimated around 900,000 homes and businesses have been left without power in the aftermath of the storm.
The storm has been downgraded from a hurricane to a tropical depression, but the risk of flooding remains severe.