Djokovic sat out of last year’s tournament to rest an elbow injury that eventually required surgery, but that pain and frustration appears to be a distant memory.
The Serbian will face Del Potro for the US Open title after beating Kei Nishikori 6-3 6-4 6-2 in their semi-final clash.
This year’s Wimbledon champion kept Nishikori under relentless pressure, carving out 17 break point opportunities and winning 80 per cent of his own first serve points to win in two hours and 23 minutes.
Meanwhile, a weary and wounded world number one Rafael Nadal retired from his US Open semi-final while trailing Del Potro 7-6(3) 6-2.
As a result, the Argentine star heads back to the Flushing Meadows final for the first time since his triumph in 2009.
Nadal, who had never before retired from a US Open match, showed signs of distress early on and was noticeably limping after a gruelling 69-minute opening set.
The showdown between Djokovic and Del Potro takes place in the iconic Arthur Ashe Stadium, with the winner set to take home a whopping £2.94million ($3.8m).
Serena Williams takes on Naomi Osaka in women’s final later today.
US Open final – When is Novak Djokovic vs Juan Martin del Potro?
The showpiece between Djokovic and Del Potro takes place tomorrow (Sunday) at 9pm BST.
Novak Djokovic vs Juan Martin del Potro – Who will win? Latest odds
N Djokovic 9/5
JM Del Potro 7/15
(Odds from Betfair)
US Open final – How to watch Novak Djokovic vs Juan Martin del Potro
The US Open is not available to watch on TV for UK viewers.
Amazon Prime Video will bring customers in the UK and Ireland live and exclusive coverage of the US Open, which runs until September 9, at the USTA Billie Jean King National Tennis Centre in New York, including multiple streams from several courts, catch-up highlights and full match replays.
This extensive coverage of the Championships will be available to Prime members in the UK and Ireland for no additional cost to their membership and represents the first time a major tennis tournament has been available exclusively on a streaming service.
If you do not currently have a subscription with Amazon, you can get a free 30-day trial of Amazon Prime by registering an account. To do this, simply head to amazon.co.uk/gp/video/offers.
Amazon Prime costs £7.99 per month but is also available for a one-off annual fee of £79.
Alternatively, a number of betting companies are also broadcasting the US Open for free on their platforms.
UK betting companies have what is called a ‘watch and bet’ licence, which means they can show matches alongside live odds.