Rossi is still second in the overall standings, but is a whopping 59 points behind Catalan ace Marc Marquez.
The cancellation of the British Grand Prix at Silverstone prevented Rossi from getting more points on the board.
But the calendar continues this weekend in Italy and Rossi admits he’s keen to keep his fans smiling.
He said: “It’s always special when you arrive at your home GP.
“There will be many friends and fans at the circuit and we’ll give it our all to make it a nice weekend.
“We were in Misano for a test a few weeks ago and we will have to pick up our work again from where we left off.
“We’ll give our maximum to start the weekend in the best way possible and do a good race, fighting for the podium.
“I hope the weather will be good, so everybody can enjoy this weekend.”
Despite Rossi’s eagerness to please a partisan Italian crowd, Marquez is looking to spoil the party.
The four-time world champion hasn’t won since the German showpiece at the Sachsenring.
Marquez, however, is feeling confident having won on Rossi’s turf last season.
“Misano is a twisty track and a slower one compared to others on the calendar, with a lot of braking and acceleration,” Marquez explained.
“It’s been a good circuit for us in the past; we have many good memories and we’ll definitely try to add a new one to the list next Sunday.
“Last year I felt good on the bike and I could ride as I like, but on Friday we’ll go on track with the usual mentality, prepared to deal with and to adapt to every situation we find.
“We’ll try to understand the conditions and the grip of the track, looking to improve session by session, hopefully during a sunny and warm weekend!”
Yamaha’s M1 bike has been blighted by electronics issues all season.
Acceleration woes continued in qualifying before the Austrian Grand Prix last month.
Rossi started the race in 14th spot after a dismal Saturday session.
However, the Italian rallied and ended up finishing the race in sixth spot.
After the qualifying shambles, M1 project leader Kouji Tsuya publicly apologised to Rossi and his team-mate Maverick Vinales.
Rossi and Vinales were involved in private testing at Aragon last week as they look to resolve the long-running issues.
Team director Massimo Meregalli reckons the only way is up for the Japanese heavyweights.
“After the successful private test [at Misano] a few weeks ago as well as the one we had in Aragon last week, we are in a positive mindset to start racing again,” he said.