Already the EPP’s leader in the European Parliament, if re-elected Mr Weber may become the next European Commission President.
Mr Juncker, who has held the EU’s top job since 2014, has signalled his intentions to step down from the position after the next European elections.
The EPP is currently the most powerful and biggest political group in the European parliament and Manfred Weber has already received declarations of support from German Chancellor Angela Merkel and Hungarian Prime Minister Viktor Orbán.
An important member of Mr Juncker’s current team of top eurocrats, Gunther Oettinger, also claimed to support the German MEP.
Last week Mr Oettinger told Politico’s Brussels Playbook: “The application process starts on September 6, so there are no applicants today.
“I consider Manfred Weber a credible and competent candidate and I am ready, within my limited possibilities, to promote him within the Christian Democratic Union.”
It is no secret the Bavarian’s candidacy will be well received in Germany but a government source claimed securing a German takeover in the European Commission is one of the top priorities for Chancellor Angela Merkel.
Elmar Brok, German MEP and a close ally of Ms Merkel also told Politico: “It’s certainly plausible that Germany has an interest because it has not held the Commission president post since Walter Hallstein in 1967.”
Mr Weber is not the only German who could succeed Mr Juncker – another name on the cards is Peter Altmaier, a long-time ally of Mrs Merkel and current German minister for economic affairs and energy.
Despite being very unlikely, British former Labour MP Denis MacShane claimed this week Mrs Merkel should not support other candidates, but become herself the first-ever female president of the European Commission and establish a reform-driven Franco-German leadership in the heart of Brussels.
In an op-ed published on the Independent, Mr MacShane argues that, while Europe could be “overloaded” by the appointment of another German “middle-rank” politician in Brussels, a woman of the political stature of Mrs Merkel could be beneficial.
He said: “Might Angela Merkel herself seek to be the first woman president of the commission?
“She has the weight, the authority, the proven government record, international reputation and status, and more political experience and skills than all of today’s European politicians put together.
“A deal with France’s President Macron could see a French central banker installed as president of the European Central Bank to reform the economic policy of the Eurozone in favour of growth and jobs with other key posts being allocated on regional, political and gender balance.”
French former foreign minister and now EU’s Chief Negotiator for Brexit, Michel Barnier, and former Finnish prime minister Alexander Stubb are also possible contenders for EU’s top job.