Federer and Paire’s clash follows Angelique Kerber’s second round tie with Johanna Larsson.
Novak Djokovic opens up the evening session on Arthur Ashe against Tennys Sandgren and he is widely considered as one of the favourites for the US Open title.
Greg Rusedski fancies the Serbian’s chances putting him ahead of Federer and Nadal, as he said: “I’d go Djokovic, Nadal and then Federer.
“I do still think he has got a shot to win it,” Rusedski told Sky Sports.
“At the Grand Slams he finds a way to lift his level so don’t discount him. He is probably going to get better (prior to the tournament).
“Yes he hasn’t won the US Open in many years (since 2008) but he is healthy.”
On Louis Armstrong, Petra Kvitova opens proceedings against YF Whang while Gael Monfils kickstarts the evening session against Kei Nishikori in one of the ties of the round.
And on Grandstand, Caroline Garcia is up in action, while Marin Cilic will be hoping to book his place in the third round.
US OPEN DAY 4 ORDER OF PLAY – UK time
Arthur Ashe Stadium
Day Session – 5pm
Johanna Larsson vs Angelique Kerber
Roger Federer vs Benoit Paire
Night Session – 12am
Novak Djokovic vs Tennys Sandgren
Maria Sharapova vs Sorana Cirstea
Louis Armstrong Stadium
Day session – 4pm
Petra Kvitova vs YF Whang
Nicolas Mahut vs Alexander Zverev
Madison Keys vs Bernarda Pera
Night session – 12am
Gael Monfils vs Kei Nishikori
Leis Tsurenko vs Caroline Wozniacki
Grandstand
Day session – 4pm
Aliaksandra Sasnovich vs Daria Kasatkina
Caroline Garcia vs Monica Puig
Lucas Pouille vs Marcos Baghdatis
Not before 5pm
Marin Cilic vs Hubert Hurkacz