Jose Mourinho has already lamented his lack of options with World Cup participation having ruled the likes of Paul Pogba and Romelu Lukaku out of the tour.
Eric Bailly and Luke Shaw are set to feature tonight as they look to take advantage of the missing Manchester United stars.
Lee Grant could make his first start for United having signed this summer with David De Gea also still on holiday following his World Cup exploits, though he will join with the squad next week.
Mourinho said: ”The pre-season is very bad, the positive thing of the pre-season is only for the young boys that have a fantastic opportunity to train with us.
“I’m worried because I’m not training (with everyone) and then I go to the Premier League without lots of players, but it is what it is and we have to try and make the best out of it with the players we have here.”
Alexis Sanchez is another notable missing name from tonight having been unable to get a visa to travel.
The Chilean has now been given the go-ahead to join up with the Red Devils though will not make it in time for tonight.
And here’s how you can see how the Red Devils get on against Club America.
How to watch Man Utd vs Club America on TV
To watch Manchester United’s first friendly of the summer, you will need an MUTV subscription, which is available on Sky Sports and Virgin Media.
The match kicks off at 3am UK time (8pm local time) on Sky channel 418.
Match build-up has been going through the night with full coverage beginning at 2am.
MUTV is also available through Google Chromecast, Amazon Fire TV, Apple TV, Xbox One and Roku streaming services.
How to watch Man Utd vs Club America online
MUTV subscribers will also be able to watch the game online for free in both the UK and US.
This costs £5.99 for a months pass, or £34.99 annually.