Federer and Nadal have won 37 Grand Slam titles between them but in 2015 and 2016 their dominance was broken.
Djokovic began to peak and was in unstoppable form as he won five out of six major tournaments available over an 18-month spell.
The Serbian’s blistering reign saw him rise to the top of the world rankings as he held all four Grand Slam titles at the same time.
However, the 31-year-old has recently undergone surgery on an elbow injury and is working his way back to top form.
He came close to his best as he won Wimbledon last week and Mouratoglou, coach of Serena Williams, believes he can once again knock Federer and Nadal off their perches.
“When Rafa and Roger were winning everything, a new guy came along and became the top dog – that was Novak and that was because he is a champion,” Mouratoglou told the BBC.
“Others have tried, but they don’t have the same mentality.
“Novak is in good physical shape and can play for a few more years.
“He dominated when Rafa and Roger played their best tennis, so he can dominate again.”
But why is Djokovic able to bounce back so strongly from such a difficult injury?
“It’s his mindset – that’s why he is back to where he is. It wasn’t the real Novak on the court during the past two years,” Mouratoglou added.
“It seems to have all come together for him during the past month, starting with reaching the French Open quarter-finals. You saw the fighting spirit was back.
“Novak never lost his game, he just lost his feel for the competition. – maybe it was his motivation.
“From a coach’s point of view, what makes a player the best of champions is not about the talent, it’s how competitive you are in the matches – how able you are in the big points, how able you are to turn a match around when you are in trouble and being able to develop your ability as a result of your work ethic.
“These things come from the mind. The champions don’t think like the regular players. There is a huge difference between both.”