Pogba joined Manchester United for a then world-record £89million fee in 2016 but has struggled to live up to his price tag.
The 24-year-old has chipped in with 12 goals and 16 assists since returning to Old Trafford but recently found himself dumped to the bench by Jose Mourinho.
Pogba’s ability has been called into question by pundits but Henderson is convinced he is the real deal.
The Liverpool midfielder said: “Because of how good he is and what is expected of him, people expect to see something special every single game.
“Of course, at times, he is human. He is going to make mistakes, he will have poor games, but ultimately he is a world-class player and will respond in the best way.
“He would not have got to where he has with a weak mentality or not caring about things.”
Henderson can empathise with Pogba because he is aware of what it is like to be publicly slammed by pundits and fans.
He has had to prove himself time and time again since joining Liverpool from Sunderland for £16m in 2011.
Despite succeeding Steven Gerrard as Liverpool captain, Henderson remains a Marmite figure among aspects of the club’s fanbase.
But he told The Times: “I don’t think it is a question of feeling appreciated because I don’t think that matters.
“I think that is the way it has been my whole career. There have always been questions: is he good enough to play for Sunderland? Is he good enough to be in the team there? Then, when I moved to Liverpool, is the price tag too big? Is he good enough?
“I feel I have answered the question but then there will always be another one and that is a good thing. That is healthy. That is me pushing myself to my limits and beyond, really. My goal is to always reach for more.
“At times people can criticise the way I play as a No 6 and say I am better further forward but, at the end of the day, the manager has huge belief in playing me in that role or he wouldn’t play me there. And he would tell me if I wasn’t doing things right.
“I would rather people question me than questioning any of my teammates. I know that I can handle that, I have been through that before and I know that it won’t change the way I think. A lot of the younger players, who maybe haven’t experienced that as much, may find it difficult.”