The Briton moves up in weight having lost his IBF world welterweight title against Errol Spence Jr last May, a fight in which he fractured his left eye socket.
He faces Belarusian Rabchenko at light-middleweight in his hometown as he looks to bounce back from successive defeats and chase his hopes of being a two-weight world champion.
Rabchenko – who has 29 wins and two defeats – has never lost from seven bouts in the UK, with Matchroom Boxing promoter Eddie Hearn even admitting he is “a bit nervous” about how Brook will fare.
With the vacant WBC silver super welterweight title up for grads, 31-year-old Brook will hope to answer the questions asked of him – having also broken his right eye socket against Gennady Golovkin in 2016.
A win for Brook could help set him up for another big fight later this year as he looks to reclaim a world belt.
But who else is in action before the night’s main event?
Kell Brook vs Sergey Rabchenko undercard
6 x 3 min rounds: Leigh Wood vs Rafael Castillo (Featherweight contest)
6 x 3 mins: Rocky Fielding vs Karel Horejsek (Super-Middleweight contest)
10 x 3 mins: Lee Appleyard vs Atif Shafiq (Super-Lightweight contest)
10 x 3 mins: Kid Galahad vs Irving Berry (Featherweight contest)
12 x 3 mins: Lenora Thomas vs Dave Allen (Commonwealth Heavyweight title)
12 x 3 mins: Gamal Yafai vs Gavin McDonnell (WBC International Super-Bantamweight title)
12 x 3 mins: Main event: Kell Brook vs Sergey Rabchenko (WBC Silver Super-Welterweight title)