Police were called to the Texas Roadhouse at Cinema ridge at about 8:45pm local time (2:45am GMT).
Four people, including a six-year-old child, were hit when a gunman opened fire outside the restaurant – unloading the entire clip.
The San Antonio Fire Department said people were taken to hospital with gunshot wounds, two people were in a critical condition and two others, including the child, had non life-threatening injuries.
Police said all the victims are related.
The gunman approached the family as they were waiting to be seated, according to police.
San Antonio Police Chief William McManus said investigators do not believe the shooting was random.
The shooter’s current location is unknown.
Police said the suspect ran towards the Holiday Inn Express.
Chief McManus did not give a description of the suspect because it was “vague”.
But surveillance footage of the shooting shows a gunman wearing a bandana at the time of the incident.
More to follow…