Cech is a doubt with a calf problem and may make way for David Ospina at Wembley today.
Arsenal boss Arsene Wenger though does have Nacho Monreal and Danny Welbeck back available.
Tottenham could bring Toby Alderweireld back in after he played against Newport in the FA Cup replay.
Harry Winks and Danny Rose also returned from long-term injuries to play in the midweek win.
Wenger said: “It is always a game that is charged emotionally. This season, if you look at the table, it is a very important game.
“For us, it is an opportunity to come back closer to the Champions League places, which is a priority.
“We lost our last two away games, at Bournemouth where we were 1-0 up, at Swansea where we were 1-0 up.
“You look at the mistakes we made and I am quite optimistic we will not make them again.”
Mauricio Pochettino thinks Tottenham can finish second, with three points today moving them up to third ahead of Liverpool and Chelsea’s matches.
“I’m a person that believes, and of course we’re going to fight for that to happen.
“The [seven-point] gap is not massive but it will be tough.”