Photos taken at the scene appear to show a blackened military jet, indicating a possible crash and fire.
Local press indicate the plane may have crashed after taking off earlier today.
It is believed the plane caught fire soon after taking off and the pilot was forced to eject from the aircraft.
Consultancy group and security experts Strategic Sentinel said on Twitter the plane had suffered “critical engine failure”.
They said: “A Royal Australian Air Force (RAAF) E/A-18G Growler Electronic Warfare Platform experienced a critical engine failure upon takeoff at Nellis AFB.
“The aircraft skidded off the runway and the pilot was able to exit the aircraft safely. Both the pilot and ground crew are safe.”
A trail of smoke could be seen rising above the base after the incident, which occurred at around 10.50am local time (6.45pm GMT).
No “serious injuries” were reported, a spokesman for the base said.
He said in a statement: “At approximately 10:45 a.m. this morning, a military aircraft experienced an incident during takeoff on the Nellis Air Force Base flight line.
“Emergency services are on scene. No serious injuries are reported.
“More information in the incident will be released as it becomes available.”
Nellis Air Force Base is located in the north-east of Las Vegas.
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