Officials are yet to confirm the motive of the incident.
The incident took place outside the Gent-st-Pietrea station to the south of the City’s centre.
The area is currently on police lockdown – however train services are believed to still be in operation.
Regional officials have confirmed investigations are ongoing.
Spokeswoman for the regional Prosecutor An Schoonjans said: “A shooting incident happened at the station of Gent-Sint-Pieters.
“The railway police have fired at a man with a knife.
“The man was taken to the hospital and injured and is in danger.
“We investigate the exact circumstances of the facts.”
A student who witnessed the incident said: “The man first entered the station loudly”.
“Then he pulled a knife and held it in the air.
“When the police ordered the man to lay down his knife, he refused.”
The man reportedly also entered a shop across the road before the incident – where he also brandished the weapon.
The shopkeeper said he “looked desperate” during the exchange.
Belgium reduced its national threat level on Monday, saying a militant attack had become less likely almost two years after bombings killed 32 people in Brussels.
The government reduced the threat level to two on a four-tier scale, indicating a medium risk.
Authorities had been on alert at level three for the serious chance of an attack since the bombings on March 22, 2016.
More to follow…