The meeting comes one day after the centrist leader spoke with Mrs May, where the pair struck a post-Brexit security deal between France and Britain.
But Emmanuel Macron will be eager to discuss EU reform with Mrs Merkel who has been absent from the centre of the bloc as she struggles to claw back power following a dismal German election victory.
The French president is planning to push through his sweeping European reforms, including plans for the creation of a European finance minister and a European Monetary Fund, and would usually turn to Germany, the EU’s financial powerhouse, for support.
But Angela Merkel has her mind on other things since September, including forming a grand coalition between her CDU and the left-wing SPD.
As cracks could begin to engulf the Franco-German partnership, the exchange is likely to be awkward for the pair after months of distance and repeated attempts by Mr Macron to work with other EU nations to push for integration.
Mr Macron initially hailed the coalition agreement as “good news” for France and for Europe, but he has not wholeheartedly embraced Mrs Merkel’s new pro-European programme of government, crucially disagreeing on the question of the European Monetary Fund, which he does not believe is needed.
He instead advocates smaller reforms to the existing European Stability Mechanism, which bails out struggling economies.
Mr Macron’s presidential victory last year marked the rebirth of the Franco-German power base as both countries looked to reassert their authority as the driving force of the Brussels club after Brexit.
And it was believed Mrs Merkel had set her sights on Paris as her number one partner to help her secure Europe’s future.
The world will now be watching to see how Mrs Merkel reacts to Mr Macron’s multimillion pound deal with Mrs May at Sandhurst Military Academy, Berkshire, yesterday.
Britain vowed to stump up mote the £44.5million after agreeing to support the country with border controls in Calais.
The pair signed a deal, which they will hope accelerates the processing of migrants seeking to come to the UK via Calais, with a reduction from six months to one month for adults and 25 days for children.
The multi-million pound agreement comes after Mr Macron threatened to scrap the 2003 Le Touquet agreement during his election campaign, which would throw the fragile border relations into chaos.