Rojo picked up his fifth yellow card of the season in the 2-2 draw with Burnley on Boxing Day, but is still available to face Southampton this weekend.
Premier League rules dictate a player receives a one-match suspension if they accumulate five yellow cards, although this threshold is lifted to 10 cautions midway through the season.
Matchweek 19 marks the halfway point of the campaign, meaning Rojo avoided a ban by just one match after picking up his latest booking in Gameweek 20.
Manchester United could also be buoyed by the potential return of both Matteo Darmian and Anthony Martial after the duo were left out in midweek.
However, Eric Bailly (ankle), Antonio Valencia (hamstring), Marouane Fellaini (knee) and Michael Carrick (heart condition) are all sidelined while Chris Smalling is also a doubt (groin).
Take a look through the gallery above to see how Manchester United could line up when they take on Southampton.