Paris Saint-Germain, Juventus and Manchester City are all said to be keen on signing the Spanish playmaker.
Isco has been a permanent figure in Zinedine Zidane’s midfielder this season scoring five goals in 24 appearances.
But his position is apparently about to be placed in jeopardy after Gareth Bale’s return to full fitness.
The Welshman has struggled with persistent calf injuries since swapping Tottenham for Real in 2013.
And he has missed majority of this season but returned to score the winning goal in the Club World Cup semi-final last week.
As Bale now gears up to cement his place in the starting line-up, alongside Karim Benzema and Cristiano Ronaldo, Isco looks likely to be the one who will make way.
According to Don Balon, PSG, Man City and Juventus have all made an approach for the midfielder.
And they could all make a move in January if Isco is dropped to the bench.
The 25-year-old is keen to play regular football to ensure he is a starter for Spain at the World Cup in Russia next year.
However, he may be hoping that Bale moves on to Manchester United or Tottenham, who are reportedly interested in bringing him back to the Premier League.
Real president Florentino Perez has reportedly grown increasingly frustrated with Bale’s injury issues.
And he could be shown the exit door next month which would save Isco’s position in the squad.