Pep Guardiola is no stranger to mixing up his starting XI for Manchester City this season, and with the fixture pile-up about to strike, who will he trust?
Sergio Aguero bagged another goal for City as they clawed to a 2-1 win over Huddersfield, but he has been used in rotation with Gabriel Jesus this season.
Elsewhere on the pitch, Bernardo Silva could be brought in to freshen the attack while Vincent Kompany is unlikely to play three games in a week.
CLICK THROUGH THE GALLERY TO REVEAL THE PREDICTED MANCHESTER CITY TEAM TO FACE SOUTHAMPTON.