While the other 28 teams in the league will be out of action, the Bulls and the Lakers will be looking to impress.
Chicago (3-11) look to be on a rebuilding phase after losing Jimmy Butler and Dwayne Wade in the summer and could be on course to finish bottom of the Eastern Conference.
Rookie Lauri Markkanen has impressed since being joining as part of the Butler deal with the Minnesota Timberwolves.
Both LeBron James and Wade have been impressed with the Finnish basketball star with the Cleveland Cavaliers duo praising his shooting ability.
The Lakers are further along in their rebuild phase and have a solid base now with several exciting young stars.
Lonzo Ball has stolen most of the headlines and attention in part to his off-court fame, but Kyle Kuzma has overshadowed his team-mate so far.
Kuzma, who joined the Lakers from the Brooklyn Nets as part as the Brook Lopez-D’Angelo Russell trade, is averaging 16.5 points and 6.8 rebounds per game.
How to watch Chicago Bulls vs Los Angeles Lakers on TV?
Tonight’s action is scheduled to start at 3:30am GMT and the game will be shown live on BT Sport 1.
BT Sport is the exclusive home of the NBA in the UK for the 2017/18 season.
They will broadcast up to seven lives games per week throughout the regular season and the first and second rounds of the playoffs, as well as every game of the conference finals and NBA Finals.
How to watch Chicago Bulls vs Los Angeles Lakers online?
If you’re unable to get in front of a TV, BT Sport customers are able to watch the game live via the app.
Alternatively you can sign up for the NBA League Pass with the option of a day pass.
The NBA League Pass lets you watch every NBA game depending on the package you select.
American viewers can catch the action online by also going for the NBA League Pass.