Joseph Muscat claimed it was more important than ever for the European Union to be open to the middle eastern states due to “creeping” instability and nations which are closing off “politically and economically”.
He went on to claim a closer union between the EU and Arab states could allow them to head in a direction “where others fear to tread”.
It follows outspoken criticism of the UK from the Maltese leader, who berated Brexit Britain in August and insisted the European Union is “much much better prepared” to take on negotiations.
Without mentioning Britain, Mr Muscat to launch an attack on UK, and possibly the United States, when he said: “We must understand the context – the world we are operating in.
“This way we can evaluate how we want to take forward our improved relations by daring to move in a direction where others fear to tread.
“We are meeting at a very important juncture for the whole world.
“This summit has a global context that should be debated because there are opportunities to take from times when instability starts creeping in.
“Protectionism seems to be raising its head again.
“Borders are slowly being sealed both politically and economically.
“This does not all bode well.
“This is the context we should consider.”
He went on to reach out to Arab leaders amassed at the summit, saying it was time for the bloc to open up to the middle east.
Mr Muscat added: “At a time when others are closing their economic borders should we be opening more avenues to work together?
“Should we open our economies to each other and allow deeper cooperation by allowing deeper access to our markets?
“My answer to both questions is yes.”
The Maltese PM’s speech comes after he said completing Brexit within two years was “practically impossible” and added he was not alone in a group of Brussels leaders who believe the exit will still not happen.
He said: “There are some who think in the same manner as I think, others are less optimistic.
“But I do think I am not alone in having this point of view.”
Mr Muscat also urged British leaders to hold a second referendum in an attempt to overturn last year’s historic vote.
He told Dutch newspaper De Volkskrant: “For the first time, I’m starting to believe that Brexit will not happen.
“I am seeing hopeful signs that indicate things will change. I see encouraging signs that the tide is turning.
“I’m not saying the Brits have made a mistake, but the mood is changing.”