England seamer Ball sprained his right ankle after it buckled in his delivery stride at the Adelaide Oval in the warm-up game with an Australia select XI.
He went off the field and was assessed by England physio Craig de Weymarn.
England expect to learn more about the injury within the next 24 hours.
But it is nevertheless concerning for the tourists after fellow fast bowler Steven Finn was forced to leave the Ashes tour with torn knee cartilage, being replaced by the uncapped Tom Curran.
England were already without Ben Stokes for the tour.
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Ball’s misfortune briefly interrupted England’s good progress, as CA struggled to 47 for four in reply to 293 all out.
The tourists had earlier lost their ninth and 10th wickets for 15 runs in 25 minutes of play, rookie leg-spinner Daniel Fallins completing a five-wicket haul on his first-class debut when he had James Anderson lbw.
It completed a sequence of five England wickets for the addition of just 22 – which began the previous evening – but meant at least they could set about making their own inroads with the ball.
Chris Woakes, and Anderson especially, allowed precious few scoring opportunities – and survival was very much the limit of Nick Larkin and Jake Carder’s ambition at the top of the order.
They managed it for almost 10 overs, before Larkin fell lbw pushing forward to Woakes for just six runs from 32 balls.
A double-change brought Ball and Craig Overton into the attack, but minimal respite until Carder timed the Somerset seamer off his legs in the 16th over for a rare boundary.
Ryan Gibson soon went after a full delivery from Ball was well-caught by a diving Dawid Malan at third slip.
Then in the first over after the tea break, Carder pulled Overton tamely to mid-on, and Will Pucovski was bowled off-stump playing no shot to leg-spinner Mason Crane.