The jets reportedly fired down in a region south of Hassia, 35km south of Oms.
The area is believed to have been home to a Hamas weapons factory, operating in the region amid the chaos across Syria.
However, media loyal to the Syrian government have claimed the location is a “copper factory”.
It is unclear if there were any casualties in the strike.
The Syrian army reportedly fired back, although the Israeli military has not confirmed or denied claims they were operating in the region.
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