Federer is vying for a place in the last four of his home-town tournament.
The seven-time winner is the big favourite and is expected to dispatch Frenchman Mannarino without too much fuss.
The world No2 has a 100% record over the 29-year-old and last faced him in the round of 32 at this event in 2013.
And they meet tonight following Marin Cilic’s win over Marton Fucsovics.
Roger Federer vs Adrian Mannarino LIVE updates
Here we go…
19.52: Here he comes.
Federer is out and salutes the crowd on his way.
The Swiss is in good spirits and limbers up at the net.
Federer closing the gap on Nadal
19.50: Roger Federer is closing the gap on Rafael Nadal as world No1 and knows success in Basel will close the gap ahead of Paris next week.
Federer is 1,960 points behind Nadal at the moment and can earn 500 points here before Paris – a 1000 point event.
And Mark Petchy thinks he’s serving as well as ever.
Petchey told Sky Sports: “The serve has been one of the crucial factors to it. His accuracy has been sensational – especially in recent weeks.
“Arguably it’s been some of the best serving of his career in terms of how tight to the line he has been.”
Cilic sees it over the line
19.40: Marin Cilic finally got the job done with a three-set win over Marton Fucsovics.
And now we can look ahead to Roger Federer in the quarter-final here in Basel.
Federer will be looking for another straight forward match up this evening as he looks to book his place in the final four.
Delay on Federer
18.30:Marin Cilic is going the distance after Marton Fucsovics won the second set 7-5.
The Swiss crowd will now be forced to wait for their hero.
In the last round…
18.25: Top seed Federer needed less than an hour to dispatch Benoit Paire 6-1 6-3 and reach the quarter-finals of the Swiss Indoors tournament on Thursday – treating his home fans to another masterclass.
The 36-year-old, chasing an eighth Basel title, has dropped only eight games in two rounds and looks in razor-sharp form as his quest for the year-end number one ranking continues.
Federer vs Mannarino
18.20: Federer has a 100% record over the 29-year-old and last faced him in the round of 32 at this event in 2013.
Mannarino is ranked 28th in the world and has never won a title on the ATP tour.
Federer meanwhile has 94 and six just this year.
He will be hoping to add another before Paris next week and then the ATP Tour Finals in London next month.
Cilic in play
18.15: So if Marin Cilic wraps this up soon we’ll be getting on with Federer vs Mannarino shortly.
Cilic won the first set after a tie-break and will be looking to win in straight sets.
Federer is hoping to make it to the last four and add to his seven titles in his hometown.
18.10: Welcome to the live coverage of Roger Federer’s quarter-final in the Swiss Indoors in Basel.
World No2 Federer faces Frenchman Adrian Mannarino for a place in the last four.
The winner takes on either David Goffin or Jack Sock.