Pulev had been the mandatory challenger to the IBF and WBA champion but misses out on his second world-title fight after hurting his shoulder while sparring.
Frenchman Takam, 36, will replace him with less than a fortnight’s notice, meaning Pulev faces a lengthy wait to fight Joshua after also losing his status as mandatory challenger with the IBF.
“I received a call from [promoter] Kalle Sauerland late afternoon to inform me that Pulev had injured his shoulder and may be ruled out of the fight – this was later confirmed by his doctor,” promoter Eddie Hearn said.
“IBF rules state that the mandatory will go to the next fighter in line which is Carlos Takam.”
Takam had been on standby for the fight and is said to be overjoyed to be facing Joshua.
Click through the gallery above to find out more about Anthony Joshua’s new opponent Carlos Takam!