This is a rematch of last year’s NLCS, which the Cubs needed six games to progress before going on to win the World Series.
But Los Angeles hold the upper hand in this year’s encounter as they hold home field advantage after finishing the season with 104 wins – better than any other side in baseball.
The Dodgers go into the match high on confidence after sweeping the Arizona Diamondbacks while the Cubs beat the Washington Nationals in five games.
In beating the Diamondbacks swiftly, the Dodgers have been able to give Clayton Kershaw plenty of rest and will start Game 1.
Meanwhile the Cubs will start with left-hander Jose Quintana just two days after his relief appearance in the Game 5 win over the Nationals.
First pitch at Dodger Stadium is scheduled to take place at 1:08am BST and here is how you can keep up with the action.
How to watch Chicago Cubs vs LA Dodgers live on TV?
The first game of the NL championship series between the Cubs and the Dodgers is live on BT Sport 1 with coverage starting at 1am (BST).
BT Sport 1, available on Sky channel 413, will show the action live while Virgin Media customers can watch on channel 531.
How to watch Chicago Cubs vs LA Dodgers live online?
If you’re unable to get in front of a TV, BT Sport customers are able to watch the game live via the app.
American viewers can catch the action online by streaming live MLB TV or by going to Watch TBS.
Game 1 October 15 at 1am BST Dodger Stadium
Game 2 October 16 at 12:30am BST Dodger Stadium
Game 3 October 18 at 2am BST Wrigley Field
Game 4 October 19 at 2am BST Wrigley Field
Game 5* October 20 at 1am BST Wrigley Field
Game 6* October 21 at 9pm BST Dodger Stadium
Game 7* October 23 at 12:30am BST Dodger Stadium