The asteroid will brush past just 31,000 miles away – about an eighth of the distance between the Earth and the moon.
At between 10 and 30 metres in size, it is believed to be bigger than the Chelyabinsk meteor which exploded above Russia, damaging thousands of buildings and injuring 1,500 people in 2013.
A broadcast of the spectacular flyby will be shown on online observatory Slooh, titled: An Uncomfortably Close Encounter.
Events will kick off on the online channel at 01.00 AM UK time on October 12, with a spokesman saying: “Slooh will train its telescopes on 2012 TC4 in an attempt to capture the fast-moving space rock as it flies between Earth and the Moon.
“We will have commentary from our asteroid experts and explore the threat they pose to our planet.
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“Asteroid TC4 is no stranger to close encounters. In 2012, the asteroid stunned observers on Earth as it plunged only 94,000 kilometres (58 miles) above our atmosphere (less than a quarter of the distance to the Moon), only a week after its discovery by the PanSTARRS observatory in Hawaii.
“On October 12th 2017, ‘2012 TC4’ will be back, once again flying by Earth on a super-close trajectory.”
A map from Nasa shows 2012 TC4 will enter the space between the Earth and the moon’s orbit diagonally from just north of east, before it shoots back out into outer space.
Nasa will use the extremely close fly by to gather valuable data on the space rock.
Michael Kelley, program scientist and Nasa headquarters lead for the TC4 observation campaign, said: “Scientists have always appreciated knowing when an asteroid will make a close approach to and safely pass the Earth because they can make preparations to collect data to characterise and learn as much as possible about it.
“This time we are adding in another layer of effort, using this asteroid flyby to test the worldwide asteroid detection and tracking network, assessing our capability to work together in response to finding a potential real asteroid threat.”