The former British Labour Prime Minister is believed to be in the running to mediate talks between the Catalan administration led by Carles Puigdemont and the conservative leadership of Mariano Rajoy on Madrid.
Relations between the two have deteriorated in recent days after the north east region defied the wishes of Madrid and held a referendum on the question of declaring independence and forming a breakaway republic.
The vote on October 1, which had been declared illegal by Madrid, triggered a show of force by the Guardia Civil and national police who tried to stop the referendum going ahead by attempting to close polling stations and used batons and rubber bullets on those attempting to vote.
Mr Rajoy has previously refused to engage in talks with the Catalan government over independence but has softened his approach in recent days, saying during an address to the nation he was “not going to close any door” to dialogue.
Mr Blair, 64, is seen as someone who could oversee any possible talks between the two sides.
He has credentials in high level talks having been involved in the Good Friday talks in Northern Ireland as well as being a Middle East envoy for the United Nations.
However critics have pointed that despite holding the UN post for almost eight years he failed to secure any real progress between Israel and Palestine.
Mr Puigdemont has called on the European Union (EU) to intervene although the bloc has tended to side with Spain. But should the EU decide to step in, one person strongly tipped to lead the talks is Federica Mogherini.
The EU’s representative for foreign affairs and security policy has a better track record over Middle East talks and won praise from the then US Secretary of State John Kerry over her handling of the Iran nuclear programme.
Other names in the frame, according to Politico, include Carl Bildt, who was a mediator in the Yugoslav wars, and the former President of Estonia Toomas Ilves.
The Norwegian politician Borge Brende is also seen to be in the running. The 52-year-old previously co-hosted the Cairo Conference on Palestine that looked at rebuilding the Gaza Strip and oversaw multilateral talks on prohibiting commercial fishing in the Arctic.
Another possibility is the former Prime Minister of Denmark Helle Thorning-Schmidt.
The former leader of the Danish Social Democrats in the European Parliament later worked as an international consultant with the Danish Confederation of Trade Unions.
MEPs in the European Union will today debate the Catalonia crisis, after facing criticism on a lack of action and half-hearted condemnation of the violence used against voters.
The emergency debate, scheduled for 3pm (local time) will focus on the “constitution, rule of law and fundamental rights in Spain in the light of the events of Catalonia”.
All the main political groups in the parliament backed the call for a debate.
The debate will give the European Parliament a chance to be more vocal about the Catalonia crisis than other EU institutions, which have been more muted, but MEPs will not vote on any resolution after the debate.
The European Commission on Monday called for “dialogue” while EU President Donald Tusk said he had asked Spanish Prime Minister Mariano Rajoy to find “ways to avoid further escalation and use of force.”