Wang Yi made the comments during a meeting with Kang Kyung-wha on the sidelines of a United Nations gathering in New York on Wednesday, according to state news agency Xinhua.
South Korea and the US say the high-tech missile-defence system called Terminal High Altitude Area Defense (THAAD) is needed to defend against the threat of North Korea.
But China claims it will do nothing to reduce tension and its powerful radar system threatens the country’s security.
China’s call for the removal of the system comes after South Korea pressed the US for additional deployment of four THAAD launching pads.
North Korea warned against the move and said South Korea is “digging up their own graves”.
In an article published by newspaper Rodong Sinmum, the regime said: “The South Korean authorities’ THAAD deployment is as foolish an act as digging up their own graves.
“The wild acts of the South Korean authorities are tantamount to the crimes committed by traitor Park Geun Hye who was keen on sycophancy toward the US and confrontation with the fellow countrymen in the north.”
The article went on to claim South Korea cannot benefit from THAAD deployment.
It added: “The South Korean ruling forces are justifying their acts of submitting toward the US, talking about ‘inevitable option’ to cope with nuclear threat from the North.
“This is a crafty trick to incite confrontation with their fellow countrymen and cover up their despicable sycophantic and traitorous nature.”
Last week, the UN Security Council condemned the hermit state’s nuclear tests by announcing measures to steep up sanctions against North Korea.