The attack on an Ariana Grande concert killed 23 people, many of whom were children, and injured another 250.
But the venue reopened earlier this month with a We Are Manchester benefit show but Fury’s heavyweight clash with New Zealander Joseph Parker will be the first time boxing has returned.
And Fury, who was born in Stockport, Greater Manchester, wants to put on a show to remember when he fights for the WBO world title, his first shot at a globla belt.
“It’s unbelievable especially after what happened there and everything to perform there,” Fury said.
“It’s my first time at the Manchester Arena, in my hometown where I was born and bred.
“Whatever has happened there with the tragedy, my heart goes out to all the families.
“There are no words that can be said. But I’m going to put on the greatest performance of my life and I’m going to bring that belt back to Manchester.”
Fury has also promised to return the belt to his family – the WBO strap was previously held Tyson Fury, who won it by beating Wladimir Klitschko.
Tyson, who has been battling depression but is hoping to return to the ring in the coming months, was in attendance at his cousin Hughie’s press conference and is expected to watch Saturday’s fight.
And the 23-year-old heavyweight Fury believes he can produce the best possible result and end Parker’s unbeaten run despite the bookmakers listing a stoppage in his favour at 11/2.
“You can look at my previous fights or whatever – no-one is going to see what’s hit him on September 23 because this is a different Hughie Fury,” he said.
“I’m so hungry and ready to put on a performance and when I say I’m going to knock him out, I’m going to knock him out.”